For active immunization of calves: Rehydrate the freeze-dried vaccine portion with the diluent provided and immediately administer the single 3-ml dose orally as soon after birth as possible. Vaccination of calves older than one day of age may not be effective.
For vaccination of cows (passive calf immunity): Administer 2 intramuscular doses 3 to 6 weeks apart during late pregnancy. Ideally, the second dose should be given within 30 days prior to calving. Revaccination with 2 doses prior to each subsequent calving is recommended. Calves must receive colostrum from vaccinated dams for protection.